Interstate 95 (I-95)

I-95 runs just east of Middletown, DE, providing the region’s primary north–south interstate connection.
It links Middletown with Wilmington to the north and the Maryland state line / Baltimore corridor to the south.

Delaware Route 1 (DE-1)

DE-1 is a major limited-access highway running east of Middletown.
It provides fast regional travel toward Dover, Smyrna, and the Delaware beaches, and connects north toward Christiana Mall and I-95.

U.S. Route 301 (US-301)

US-301 passes directly west of Middletown and serves as one of the town’s most important corridors.
It provides a key north–south route toward Delaware City, Chesapeake City (MD), and connects with DE-1 and I-95 for broader travel.

Delaware Route 299 (DE-299)

DE-299 (Middletown Warwick Road / Main Street) runs through the center of Middletown.
It serves as a major east–west corridor connecting the town with Odessa, US-301, and nearby communities.

Delaware Route 71 (DE-71)

DE-71 travels north–south through Middletown, often overlapping with DE-896 in parts.
It links Middletown with Townsend to the south and the Summit Bridge / Glasgow area to the north.

Delaware Route 896 (DE-896)

DE-896 runs along the western edge of Middletown and provides a major regional connection.
It links Middletown with Newark, University of Delaware, and the Summit Bridge over the Chesapeake & Delaware Canal.

Delaware Route 15 (DE-15)

DE-15 passes near the western outskirts of Middletown.
It provides a north–south local and regional connector linking Middletown’s surrounding rural areas with Smyrna and Clayton.