Interstate 95 (I‑95 / New Jersey Turnpike)
I‑95 (the New Jersey Turnpike) runs through the eastern part of Newark, providing major north–south connectivity. NJ.gov+2Teknopedia+2
It links Newark to southern New Jersey, New Brunswick, and northern New Jersey / New York. Teknopedia+1

Interstate 78 (I‑78)
I‑78 passes through the southern part of Newark.
It provides an east–west corridor connecting Newark with Union County and beyond. East Coast Roads

Interstate 280 (I‑280)
I‑280 runs through the northern part of Newark, linking to western Essex and Morris Counties. NJ.gov+1
It serves as a key connector, including to I‑95 / the Turnpike in the east.

U.S. Route 1 / 9 (US‑1/9)
US‑1/9 runs through Newark, providing important regional north–south access. NJ.gov
It links Newark with Elizabeth, Linden, and other southern New Jersey communities. i95exitguide.com

U.S. Route 22 (US‑22)
US‑22 runs along Newark’s southern edge, connecting with I‑78 and other major routes. NJ.gov+1

New Jersey Route 21 (NJ‑21)
NJ‑21 (McCarter Highway) runs through Newark, especially along the Passaic River. 
It provides a north–south surface route linking downtown Newark with I‑280 and US‑22. 

Garden State Parkway (GSP)
The Garden State Parkway passes just west of or near Newark and forms part of the regional north–south network.